VITAMIN D STATUS IN THALASSEMIA MAJOR: AN UPDATE

01 October 2013

The article entitled "Vitamin D Status in Thalassemia Major: An Update" has been published in the international journal "MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES", edited by dr. Vincenzo De Sanctis.

Ashraf Soliman,¹ Vincenzo De Sanctis,² and Mohamed Yassin³
¹Departments of Pediatrics, Hamad Medical Center (HMC), Doha (Qatar)
²Pediatric, Adolescent Outpatient Clinic, Quisisana Hospital, 44121 Ferrara (Italy)
³Department of Hematology, Alamal Hospital, HMC, Doha, (Qatar)

Abstract

The survival of patients with thalassemia major has progressively improved with advances in therapy; however, osteoporosis and cardiac dysfunction remain frequent complications. Adequate circulating levels of vitamin D are essential for optimal skeletal health and reducing fracture risk. Vitamin D deficiency and insufficiency is reported to be high in thalassemic patients in many countries despite the presence of good sunshine and routine prescription of 400–1,000 IU vitamin D per day. The risk of vitamin D deficiency in thalassemia and its relation to bone disease; including osteoporosis, rickets, scoliosis, spinal deformities and fractures as well as to cardiac dysfunction is discussed in this mini-review. Monitoring and maintaining normal serum level of 25-OH vitamin D through oral intake of vitamin D and early correction of VDD by oral or parental use of vitamin D may significantly improve bone mineral accretion and ameliorate cardiac function.

PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/24106607

VITAMIN D STATUS IN THALASSEMIA MAJOR: AN UPDATE

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